What Is “Tolerance” and “Tolerance Education”? Philosophical Perspectives

Mucosal Tolerance a Barrier? Perspectives on Mucosal Vaccines: Is

P-value: What is and what is not

The misinterpretation and misuse of p-value have been increasing for decades. In March 2016, the American Statistical Association released a statement to warn about the use and interpretation of p-value. In this study, we provided a definition and discussion of p-value and emphasized the importance of its accurate interpretation.    

Tolerance in Kidney Transplantation: What Is on the B Side?

Regulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. Their study is, however, in its infancy with still little knowledge and consensus on their origin, phenotype, and mechanism...

Natural Killer Cell Education and Tolerance

Natural killer (NK) cells play a key role in the immune response to certain infections and malignancies by direct cytolysis of infected or transformed cells and by secretion of potent immune mediators. NK cells express an array of activating receptors that recognize self-molecules. If not restrained by inhibitory receptors recognizing major histocompatibility complex (MHC) class I proteins on t...

Philosophical Perspectives

Philosophical perspectives are worldviews that define the nature of the world, the individual’s place in it, and the possible relationships to that world and its parts. Learning and instructional theories are developed with respect to a particular set of assumptions regarding what it means to know and learn. It is our contention that when situational variables require some decision on the part ...